Seroatlas · Human Serome Atlas

HDGFL1

Hepatoma-derived growth factor-like protein 1

Also known as: dJ309H15.1, Hdgfrp1, HDGL1_HUMAN, HRP-1, PWWP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TGJ6
Gene: HDGFL1
Ensembl: ENSG00000112273
Chromosome: 6
Canonical length: 251 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q5TGJ6|HDGFL1
     1  MSAYGMPMYK SGDLVFAKLK GYAHWPARIE HMTQPNRYQV FFFGTHETAF LSPKRLFPYK
    61  ECKEKFGKPN KRRGFSAGLW EIENNPTVQA SDCPLASEKG SGDGPWPEPE AAEGDEDKPT
   121  HAGGGGDELG KPDDDKPTEE EKGPLKRSAG DPPEDAPKRP KEAAPDQEEE AEAERAAEAE
   181  RAAAAAAATA VDEESPFLVA VENGSAPSEP GLVCEPPQPE EEELREEEVA DEEASQEWHA
   241  EAPGGGDRDS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDGFL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

testis: 88 nTPM
pituitary gland: 0.4 nTPM
ovary: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late primary spermatocytes: 3.9 nCPM
early spermatids: 0.8 nCPM
late spermatids: 0.8 nCPM
early primary spermatocytes: 0.4 nCPM
differentiating spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.5 nTPM
basal ganglia: 0.9 nTPM
white matter: 0.7 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin remodeling

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDGFL1 as an antibody target. Whether an autoantibody or antibody against HDGFL1 could matter depends on whether native HDGFL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDGFL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDGFL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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