HDGF

Protein identityUniProt · HPA

UniProt accession

P51858

Gene

HDGF

Ensembl

ENSG00000143321

Chromosome

1

Canonical length

240 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>P51858|HDGF
     1  MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP
    61  KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCVE EPEPEPEAAE
   121  GDGDKKGNAE GSSDEEGKLV IDEPAKEKNE KGALKRRAGD LLEDSPKRPK EAENPEGEEK
   181  EAATLEVERP LPMEVEKNST PSEPGSGRGP PQEEEEEEDE EEEATKEDAE APGIRDHESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDGF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

288 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for HDGF from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.64

gnomAD pLI

0.27

gnomAD missense Z

1.25

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromatin remodeling
• negative regulation of transcription by RNA polymerase II
• positive regulation of cell division
• positive regulation of transcription by RNA polymerase II
• protein localization to nucleus
• signal transduction

Molecular functions

• actin binding
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• growth factor activity
• heparin binding
• nucleotide binding
• RNA binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• transcription corepressor activity
• transcription corepressor binding
• tubulin binding

Cellular components

• cytoplasm
• extracellular region
• extracellular space
• nucleoplasm
• nucleus
• transcription repressor complex

Protein domainsUniProt · Pfam · InterPro

• PWWP domain
• PWWP domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Disulfide bond
• DNA-binding
• Growth factor
• Heparin-binding
• Isopeptide bond
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repressor
• Secreted
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of HDGF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HDGFL2
• YBX1
• VIM
• NCL