Seroatlas · Human Serome Atlas

HDAC11

Histone deacetylase 11

Also known as: HDA11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DB2
Gene: HDAC11
Ensembl: ENSG00000163517
Chromosome: 3
Canonical length: 347 aa
Protein class: Enzymes, FDA approved drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q96DB2|HDAC11
     1  MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDSML
    61  VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG
   121  TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL
   181  DAHQGNGHER DFMDDKRVYI MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER
   241  NIKKSLQEHL PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRRVPILMVT
   301  SGGYQKRTAR IIADSILNLF GLGLIGPESP SVSAQNSDTP LLPPAVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDAC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 94 nTPM
testis: 80 nTPM
midbrain: 75 nTPM
amygdala: 72 nTPM
hippocampal formation: 69 nTPM
spinal cord: 60 nTPM

Single-cell type

late spermatids: 1,215 nCPM
early spermatids: 413 nCPM
late primary spermatocytes: 125 nCPM
oligodendrocytes: 65 nCPM
retinal ganglion cells: 39 nCPM
enterocytes: 35 nCPM

Immune cell

NK-cell: 9.6 nTPM
eosinophil: 5.9 nTPM
gdT-cell: 3.4 nTPM
memory CD4 T-cell: 3.2 nTPM
naive CD4 T-cell: 3 nTPM
classical monocyte: 2.6 nTPM

Brain region

white matter: 155 nTPM
basal ganglia: 145 nTPM
cerebral cortex: 123 nTPM
midbrain: 114 nTPM
thalamus: 114 nTPM
medulla oblongata: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.01
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HDAC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HDAC6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDAC11 as an antibody target. Whether an autoantibody or antibody against HDAC11 could matter depends on whether native HDAC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDAC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDAC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...