Seroatlas · Human Serome Atlas

HCP5

HLA class I histocompatibility antigen protein P5

Also known as: HCP5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6MZN7
Gene
HCP5
Canonical length
132 aa

OverviewNCBI Gene

No narrative summary is available for HCP5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q6MZN7|HCP5
     1  MLLRMSEHRN EALGNYLEMR LKSSFLRGLG SWKSNPLRLG GWTILLTLTM GQGEPGGPQG
    61  DPWVPHELLL PSLCDSSHAS SWGSGSITCA WRGGDSSSHP LVSGHILSNS PVAAVMCSSM
   121  GTHLSPFKGT LL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCP5 as an antibody target. Whether an autoantibody or antibody against HCP5 could matter depends on whether native HCP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HCP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HCP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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