Seroatlas · Human Serome Atlas

HCG22

Protein PBMUCL2

Also known as: PBMU2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: E2RYF7
Gene: HCG22
Canonical length: 251 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for HCG22 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>E2RYF7|HCG22
     1  MPRYVPLLLL LLLLRCSERG GGVNFGEKDA KVPGTWRDGV RVPGEGASWD SDRASPERRY
    61  GIVGLSQSIS TKHPETSPKD SRIRENDVTA DGRTTEDHIT ADPGTTEDSV TADPGTTEDN
   121  VTVDPGTTEG SVTADPATTK DYVSADPGTT KDSVTADPGT TENFVTADPG TTKDSITADP
   181  RTTEDSVTAD PGTTKHSITV DPGTTEDSVT ADPGTTKHSI TADPGTTEDS VTADPGTTED
   241  ETTKHGDTHL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCG22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM
cerebral cortex: 0 nTPM

Single-cell type

microglia: 134 nCPM
esophageal apical cells: 22 nCPM
ependymal cells: 9.3 nCPM
bergmann glia: 8.2 nCPM
astrocytes: 6.7 nCPM
esophageal suprabasal cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

EZH Inhibitory Protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCG22 as an antibody target. Whether an autoantibody or antibody against HCG22 could matter depends on whether native HCG22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCG22 is annotated as secreted, so native HCG22 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HCG22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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