HCFC1R1
Host cell factor C1 regulator 1
Also known as: FLJ20568, HPIP, HPIP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NWW0
- Gene
- HCFC1R1
- Ensembl
- ENSG00000103145
- Chromosome
- 16
- Canonical length
- 138 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
138 residues, UniProt reviewed canonical sequence.
>Q9NWW0|HCFC1R1
1 MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE QEPLRKQFLS
61 EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL LLWRYPGSLI PEALRLLRLG
121 DTPSPPYPAT PAGDIMELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HCFC1R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 480 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 480 nTPM
- blood vessel: 356 nTPM
- basal ganglia: 287 nTPM
- amygdala: 254 nTPM
- cerebral cortex: 223 nTPM
- midbrain: 203 nTPM
Single-cell type
- vascular smooth muscle cells: 229 nCPM
- decidual stromal cells: 227 nCPM
- smooth muscle cells: 188 nCPM
- hepatic stellate cells: 187 nCPM
- peritubular myoid cells: 172 nCPM
- extravillous trophoblasts: 157 nCPM
Immune cell
- myeloid DC: 45 nTPM
- T-reg: 37 nTPM
- classical monocyte: 37 nTPM
- intermediate monocyte: 28 nTPM
- non-classical monocyte: 27 nTPM
- NK-cell: 26 nTPM
Brain region
- pons: 162 nTPM
- cerebral cortex: 158 nTPM
- midbrain: 156 nTPM
- hypothalamus: 154 nTPM
- thalamus: 150 nTPM
- basal ganglia: 145 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.53
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Host cell factor C1 regulator 1
- HCF-1 beta-propeller-interacting protein family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HCFC1R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HCFC1R1 as an antibody target. Whether an autoantibody or antibody against HCFC1R1 could matter depends on whether native HCFC1R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HCFC1R1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HCFC1R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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