Seroatlas · Human Serome Atlas

HCAR1

Hydroxycarboxylic acid receptor 1

Also known as: FKSG80, GPR104, GPR81, HCA1, HCAR1_HUMAN, LACR1, TA-GPCR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXC0
Gene: HCAR1
Ensembl: ENSG00000196917
Chromosome: 12
Canonical length: 346 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q9BXC0|HCAR1
     1  MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS TVYLFNLAVA
    61  DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA GSIVFLTVVA ADRYFKVVHP
   121  HHAVNTISTR VAAGIVCTLW ALVILGTVYL LLENHLCVQE TAVSCESFIM ESANGWHDIM
   181  FQLEFFMPLG IILFCSFKIV WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR
   241  LYFLWTVPSS ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK
   301  QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 38 nTPM
breast: 11 nTPM
adipose tissue: 5.1 nTPM
seminal vesicle: 4.7 nTPM
salivary gland: 4.6 nTPM
spleen: 2.1 nTPM

Single-cell type

breast hormone-responsive cells: 16 nCPM
early spermatids: 14 nCPM
renal collecting duct intercalated cells: 12 nCPM
salivary acinar cells: 9.2 nCPM
transitional alveolar cells: 9.1 nCPM
adipocytes: 8.5 nCPM

Immune cell

basophil: 1.7 nTPM
neutrophil: 1.1 nTPM
NK-cell: 0.4 nTPM
naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 5.5 nTPM
white matter: 4.9 nTPM
cerebral cortex: 4.2 nTPM
choroid plexus: 4.1 nTPM
medulla oblongata: 3.9 nTPM
amygdala: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCAR1 as an antibody target. Whether an autoantibody or antibody against HCAR1 could matter depends on whether native HCAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCAR1 is annotated at the cell surface, where native HCAR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HCAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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