HBQ1
Hemoglobin subunit theta-1
Also known as: HBAT_HUMAN, HBQ
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P09105
- Gene
- HBQ1
- Ensembl
- ENSG00000086506
- Chromosome
- 16
- Canonical length
- 142 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Lipid droplets
OverviewNCBI Gene
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
142 residues, UniProt reviewed canonical sequence.
>P09105|HBQ1
1 MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS PGSSQVRAHG
61 QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ LLGHCLLVTL ARHYPGDFSP
121 ALQASLDKFL SHVISALVSE YRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HBQ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 24 nTPM
- amygdala: 14 nTPM
- basal ganglia: 12 nTPM
- cerebral cortex: 9.7 nTPM
- hippocampal formation: 6.6 nTPM
- hypothalamus: 4.5 nTPM
Single-cell type
- erythrocytes: 222 nCPM
- platelets: 106 nCPM
- erythrocyte progenitors: 88 nCPM
- megakaryocytes: 80 nCPM
- differentiating spermatogonia: 49 nCPM
- oocytes: 23 nCPM
Immune cell
- total PBMC: 4.3 nTPM
- MAIT T-cell: 1.3 nTPM
- neutrophil: 1.3 nTPM
- gdT-cell: 1.1 nTPM
- memory CD8 T-cell: 0.9 nTPM
- naive CD8 T-cell: 0.6 nTPM
Brain region
- cerebral cortex: 8 nTPM
- amygdala: 7.7 nTPM
- hypothalamus: 7.5 nTPM
- basal ganglia: 7.1 nTPM
- white matter: 5.8 nTPM
- hippocampal formation: 5.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.59
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HBQ1 as an antibody target. Whether an autoantibody or antibody against HBQ1 could matter depends on whether native HBQ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HBQ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HBQ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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