Seroatlas · Human Serome Atlas

HBP1

HMG box-containing protein 1

Also known as: HBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60381
Gene: HBP1
Ensembl: ENSG00000105856
Chromosome: 7
Canonical length: 514 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of lipid transport; negative regulation of reactive oxygen species biosynthetic process; and negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Biomarker of osteoarthritis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>O60381|HBP1
     1  MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC DEHMELDDLP
    61  ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE TTYRENEVDW LTELANIATS
   121  PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVSSSSK SEPAFPHHHW KEETPVRHER
   181  ANSESESGIF CMSSLSDDDD LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA
   241  EGCDNEEDLQ MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH
   301  PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV FDTFKSYDFT
   361  PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC GSPGSSQLSS NSLYAKAVKN
   421  HSSGTVSATS PNKCKRPMNA FMLFAKKYRV EYTQMYPGKD NRAISVILGD RWKKMKNEER
   481  RMYTLEAKAL AEEQKRLNPD CWKRKRTNSG SQQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 82 nTPM
skin: 66 nTPM
blood vessel: 63 nTPM
adipose tissue: 54 nTPM
testis: 54 nTPM
esophagus: 51 nTPM

Single-cell type

late spermatids: 487 nCPM
oligodendrocytes: 110 nCPM
early spermatids: 104 nCPM
bergmann glia: 81 nCPM
microglia: 77 nCPM
distal convoluted tubule cells: 68 nCPM

Immune cell

neutrophil: 147 nTPM
basophil: 143 nTPM
total PBMC: 92 nTPM
eosinophil: 80 nTPM
non-classical monocyte: 65 nTPM
intermediate monocyte: 62 nTPM

Brain region

white matter: 47 nTPM
medulla oblongata: 35 nTPM
basal ganglia: 32 nTPM
cerebellum: 30 nTPM
pons: 30 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.64
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ataxin, AXH domain
High mobility group box domain
Ataxin, AXH domain superfamily
High mobility group box domain superfamily
HMG (high mobility group) box
Ataxin-1 and HBP1 module (AXH)
HMG box-containing protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HBP1 as an antibody target. Whether an autoantibody or antibody against HBP1 could matter depends on whether native HBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...