HBM
Hemoglobin subunit mu
Also known as: HBAP2, HBK, HBM_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6B0K9
- Gene
- HBM
- Ensembl
- ENSG00000206177
- Chromosome
- 16
- Canonical length
- 141 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
141 residues, UniProt reviewed canonical sequence.
>Q6B0K9|HBM
1 MLSAQERAQI AQVWDLIAGH EAQFGAELLL RLFTVYPSTK VYFPHLSACQ DATQLLSHGQ
61 RMLAAVGAAV QHVDNLRAAL SPLADLHALV LRVDPANFPL LIQCFHVVLA SHLQDEFTVQ
121 MQAAWDKFLT GVAVVLTEKY RLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HBM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 433 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 433 nTPM
- spleen: 17 nTPM
- placenta: 5.9 nTPM
- lung: 4 nTPM
- liver: 3.1 nTPM
- kidney: 1.5 nTPM
Single-cell type
- erythrocytes: 1,662 nCPM
- erythrocyte progenitors: 902 nCPM
- late spermatids: 3 nCPM
- differentiating spermatogonia: 2.5 nCPM
- undifferentiated spermatogonia: 1.7 nCPM
- hofbauer cells: 1.3 nCPM
Immune cell
- total PBMC: 6.9 nTPM
- NK-cell: 0.7 nTPM
- eosinophil: 0.4 nTPM
- plasmacytoid DC: 0.4 nTPM
- gdT-cell: 0.2 nTPM
- basophil: 0 nTPM
Brain region
- cerebral cortex: 1.5 nTPM
- basal ganglia: 1.1 nTPM
- amygdala: 0.9 nTPM
- choroid plexus: 0.7 nTPM
- medulla oblongata: 0.7 nTPM
- pons: 0.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.37
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HBM as an antibody target. Whether an autoantibody or antibody against HBM could matter depends on whether native HBM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HBM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HBM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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