HBE1
Hemoglobin subunit epsilon
Also known as: HBE, HBE_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P02100
- Gene
- HBE1
- Ensembl
- ENSG00000213931
- Chromosome
- 11
- Canonical length
- 147 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>P02100|HBE1
1 MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS SPSAILGNPK
61 VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD PENFKLLGNV MVIILATHFG
121 KEFTPEVQAA WQKLVSAVAI ALAHKYHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HBE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 1.2 nTPM
Expression across tissuesHPA
Tissue
- liver: 1.2 nTPM
- placenta: 0.7 nTPM
- adipose tissue: 0.6 nTPM
- cerebral cortex: 0.6 nTPM
- ovary: 0.6 nTPM
- testis: 0.5 nTPM
Single-cell type
- late spermatids: 0.3 nCPM
- astrocytes: 0.1 nCPM
- early spermatids: 0.1 nCPM
- endometrial stromal cells: 0.1 nCPM
- extravillous trophoblasts: 0.1 nCPM
- migrating cytotrophoblasts: 0.1 nCPM
Immune cell
- neutrophil: 0.2 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- white matter: 3.3 nTPM
- hypothalamus: 2.8 nTPM
- cerebral cortex: 2.7 nTPM
- medulla oblongata: 2.2 nTPM
- basal ganglia: 2.1 nTPM
- pons: 1.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.21
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HBE1 as an antibody target. Whether an autoantibody or antibody against HBE1 could matter depends on whether native HBE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HBE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HBE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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