Seroatlas · Human Serome Atlas

HAS3

Hyaluronan synthase 3

Also known as: HYAS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00219
Gene
HAS3
Ensembl
ENSG00000103044
Chromosome
16
Canonical length
553 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Microtubules
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>O00219|HAS3
     1  MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS
    61  LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM
   121  VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA
   181  STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG
   241  VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE
   301  DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS
   361  YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG
   421  IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG
   481  LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG
   541  KKPEQYSLAF AEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
87 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 87 nTPM
  • esophagus: 32 nTPM
  • lung: 19 nTPM
  • stomach: 12 nTPM
  • vagina: 11 nTPM
  • skin: 9.2 nTPM

Single-cell type

  • basal keratinocytes: 127 nCPM
  • urothelial cells: 114 nCPM
  • epididymal basal cells: 109 nCPM
  • suprabasal keratinocytes: 109 nCPM
  • esophageal suprabasal cells: 92 nCPM
  • esophageal basal cells: 79 nCPM

Immune cell

  • eosinophil: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • gdT-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM

Brain region

  • midbrain: 4.1 nTPM
  • cerebellum: 4 nTPM
  • cerebral cortex: 3.8 nTPM
  • basal ganglia: 3.7 nTPM
  • pons: 3.7 nTPM
  • hypothalamus: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.88
gnomAD missense Z
2.56
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAS3 as an antibody target. Whether an autoantibody or antibody against HAS3 could matter depends on whether native HAS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAS3 is annotated at the cell surface, where native HAS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HAS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HAS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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