Seroatlas · Human Serome Atlas

HAPSTR2

HUWE1-associated protein modifying stress responses 2

Also known as: HAPR2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A7P0TBJ1
Gene: HAPSTR2
Canonical length: 273 aa
Quaternary structure: Homooligomer

OverviewNCBI Gene

No narrative summary is available for HAPSTR2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>A0A7P0TBJ1|HAPSTR2
     1  MEEQQKEGEA EVAEHWFSKW ERQCLAEAEQ EEQLPPELQE EAAAELAGLK SEKQKLWHLF
    61  QISATAVAQL YKDSGCQQQG LSMWDPFQNA AMAVTSLYKE SGDAHQRSFD LGVQVGHQRR
   121  IKDVLEWVKK GRSTIRREDL ISFLCGKVPP APPPPRTPRT PPKPPTGVTS QAVATESSSS
   181  VDVDLQPFQE AIALHGLSGA MAGISMRSGD SPQDSGVASS GRRKTSFLED DLNPFDSEEL
   241  ALHLDSGGIR KRTSAQCSDG ITDSPIQKRN RMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAPSTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of HAPSTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HUWE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAPSTR2 as an antibody target. Whether an autoantibody or antibody against HAPSTR2 could matter depends on whether native HAPSTR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAPSTR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAPSTR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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