HAO2
2-Hydroxyacid oxidase 2
Also known as: GIG16, HAOX2, HAOX2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYQ3
- Gene
- HAO2
- Ensembl
- ENSG00000116882
- Chromosome
- 1
- Canonical length
- 351 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Vesicles,Cytosol
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Canonical amino-acid sequenceUniProt
351 residues, UniProt reviewed canonical sequence.
>Q9NYQ3|HAO2
1 MSLVCLTDFQ AHAREQLSKS TRDFIEGGAD DSITRDDNIA AFKRIRLRPR YLRDVSEVDT
61 RTTIQGEEIS APICIAPTGF HCLVWPDGEM STARAAQAAG ICYITSTFAS CSLEDIVIAA
121 PEGLRWFQLY VHPDLQLNKQ LIQRVESLGF KALVITLDTP VCGNRRHDIR NQLRRNLTLT
181 DLQSPKKGNA IPYFQMTPIS TSLCWNDLSW FQSITRLPII LKGILTKEDA ELAVKHNVQG
241 IIVSNHGGRQ LDEVLASIDA LTEVVAAVKG KIEVYLDGGV RTGNDVLKAL ALGAKCIFLG
301 RPILWGLACK GEHGVKEVLN ILTNEFHTSM ALTGCRSVAE INRNLVQFSR LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HAO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.23
- Highest tissue expression
- 398 nTPM
Expression across tissuesHPA
Tissue
- liver: 398 nTPM
- kidney: 283 nTPM
- thymus: 22 nTPM
- skin: 4.1 nTPM
- breast: 0.6 nTPM
- adrenal gland: 0.5 nTPM
Single-cell type
- hepatocytes: 397 nCPM
- proximal tubule cells: 110 nCPM
- hepatic stellate cells: 6.5 nCPM
- cholangiocytes: 4.7 nCPM
- kupffer cells: 4.1 nCPM
- distal convoluted tubule cells: 3.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 3 nTPM
- thalamus: 2 nTPM
- medulla oblongata: 1.9 nTPM
- pons: 1.9 nTPM
- amygdala: 1.8 nTPM
- cerebellum: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.26
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.07
- DepMap mean gene effect
- -0.28
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HAO2 as an antibody target. Whether an autoantibody or antibody against HAO2 could matter depends on whether native HAO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HAO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HAO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...