HAGHL
Hydroxyacylglutathione hydrolase-like protein
Also known as: HAGHL_HUMAN, MGC2605
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PII5
- Gene
- HAGHL
- Ensembl
- ENSG00000103253
- Chromosome
- 16
- Canonical length
- 290 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
290 residues, UniProt reviewed canonical sequence.
>Q6PII5|HAGHL
1 MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA
61 RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI HVRCLLTPGH TAGHMSYFLW
121 EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ QMYQSLAELG TLPPETKVFC GHEHTLSNLE
181 FAQKVEPCND HVRAKLSWAK ARPLSRRGKR VGGEGTGFGV GGALRQGLMV TGACGHSRRG
241 MRMTCPLCRR LWARSASTTP SCGWREYGCC PGASTVTWTL RKASGDCVLGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HAGHL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 36 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 36 nTPM
- spinal cord: 34 nTPM
- cerebellum: 30 nTPM
- cerebral cortex: 29 nTPM
- midbrain: 29 nTPM
- hippocampal formation: 23 nTPM
Single-cell type
- ependymal cells: 197 nCPM
- respiratory ciliated cells: 120 nCPM
- epididymal efferent duct ciliated cells: 115 nCPM
- fallopian tube ciliated cells: 88 nCPM
- hofbauer cells: 67 nCPM
- bergmann glia: 61 nCPM
Immune cell
- memory B-cell: 8.8 nTPM
- NK-cell: 4.3 nTPM
- memory CD8 T-cell: 4.2 nTPM
- MAIT T-cell: 4.1 nTPM
- gdT-cell: 3.6 nTPM
- plasmacytoid DC: 3.5 nTPM
Brain region
- choroid plexus: 47 nTPM
- cerebellum: 32 nTPM
- basal ganglia: 30 nTPM
- spinal cord: 30 nTPM
- medulla oblongata: 30 nTPM
- white matter: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.72
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HAGHL as an antibody target. Whether an autoantibody or antibody against HAGHL could matter depends on whether native HAGHL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HAGHL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HAGHL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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