Seroatlas · Human Serome Atlas

HAGH

Hydroxyacylglutathione hydrolase, mitochondrial

Also known as: GLO2, GLO2_HUMAN, GLXII, HAGH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16775
Gene: HAGH
Ensembl: ENSG00000063854
Chromosome: 16
Canonical length: 308 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q16775|HAGH
     1  MVVGRGLLGR RSLAALGAAC ARRGLGPALL GVFCHTDLRK NLTVDEGTMK VEVLPALTDN
    61  YMYLVIDDET KEAAIVDPVQ PQKVVDAARK HGVKLTTVLT THHHWDHAGG NEKLVKLESG
   121  LKVYGGDDRI GALTHKITHL STLQVGSLNV KCLATPCHTS GHICYFVSKP GGSEPPAVFT
   181  GDTLFVAGCG KFYEGTADEM CKALLEVLGR LPPDTRVYCG HEYTINNLKF ARHVEPGNAA
   241  IREKLAWAKE KYSIGEPTVP STLAEEFTYN PFMRVREKTV QQHAGETDPV TTMRAVRREK
   301  DQFKMPRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAGH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 221 nTPM

Expression across tissuesHPA

Tissue

liver: 221 nTPM
skeletal muscle: 188 nTPM
tongue: 146 nTPM
heart muscle: 130 nTPM
adrenal gland: 107 nTPM
cerebral cortex: 107 nTPM

Single-cell type

late primary spermatocytes: 429 nCPM
oocytes: 281 nCPM
hepatocytes: 232 nCPM
early spermatids: 227 nCPM
enterocytes: 190 nCPM
erythrocytes: 183 nCPM

Immune cell

non-classical monocyte: 89 nTPM
eosinophil: 65 nTPM
plasmacytoid DC: 65 nTPM
intermediate monocyte: 59 nTPM
T-reg: 43 nTPM
basophil: 37 nTPM

Brain region

hippocampal formation: 88 nTPM
cerebral cortex: 85 nTPM
white matter: 81 nTPM
thalamus: 77 nTPM
hypothalamus: 75 nTPM
pons: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: -1.12
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAGH as an antibody target. Whether an autoantibody or antibody against HAGH could matter depends on whether native HAGH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAGH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAGH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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