Seroatlas · Human Serome Atlas

HACD4

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4

Also known as: Em:AL662879.1, HACD4_HUMAN, PTPLAD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWC8
Gene: HACD4
Ensembl: ENSG00000188921
Chromosome: 9
Canonical length: 232 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Involved in fatty acid elongation and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q5VWC8|HACD4
     1  MGPLALPAWL QPRYRKNAYL FIYYLIQFCG HSWIFTNMTV RFFSFGKDSM VDTFYAIGLV
    61  MRLCQSVSLL ELLHIYVGIE SNHLLPRFLQ LTERIIILFV VITSQEEVQE KYVVCVLFVF
   121  WNLLDMVRYT YSMLSVIGIS YAVLTWLSQT LWMPIYPLCV LAEAFAIYQS LPYFESFGTY
   181  STKLPFDLSI YFPYVLKIYL MMLFIGMYFT YSHLYSERRD ILGIFPIKKK KM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HACD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 11 nTPM
lung: 7.8 nTPM
placenta: 6 nTPM
cervix: 4.9 nTPM
thymus: 4.8 nTPM
ovary: 4.3 nTPM

Single-cell type

platelets: 500 nCPM
megakaryocytes: 173 nCPM
neutrophils: 139 nCPM
respiratory ciliated cells: 107 nCPM
neutrophil progenitors: 104 nCPM
hofbauer cells: 101 nCPM

Immune cell

basophil: 21 nTPM
eosinophil: 14 nTPM
neutrophil: 12 nTPM
non-classical monocyte: 11 nTPM
intermediate monocyte: 11 nTPM
myeloid DC: 10 nTPM

Brain region

choroid plexus: 9.5 nTPM
cerebral cortex: 8.7 nTPM
cerebellum: 7.6 nTPM
white matter: 6.7 nTPM
amygdala: 6.3 nTPM
basal ganglia: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
DepMap mean gene effect: 0.21
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HACD4 as an antibody target. Whether an autoantibody or antibody against HACD4 could matter depends on whether native HACD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HACD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HACD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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