Seroatlas · Human Serome Atlas

H2BN1

Histone H2B.N

Also known as: H2BN1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DW85
Gene
H2BN1
Canonical length
118 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for H2BN1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P0DW85|H2BN1
     1  MYFICLNDLR FPKNKTELYF PVKKKHEWAN SATGKKRRWR KKRRKEAYFS YMGKILKQIH
    61  PDFSGRSWVL YALGALNAWQ LEWVSLEAFR LSFYNHRRAI TGREILGAVK QRSSQKSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 0.8 nTPM
  • adrenal gland: 0.7 nTPM
  • rectum: 0.7 nTPM
  • testis: 0.7 nTPM
  • colon: 0.6 nTPM
  • small intestine: 0.5 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • MAIT T-cell: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 1.1 nTPM
  • white matter: 0.9 nTPM
  • cerebral cortex: 0.8 nTPM
  • basal ganglia: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BN1 as an antibody target. Whether an autoantibody or antibody against H2BN1 could matter depends on whether native H2BN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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