Seroatlas · Human Serome Atlas

H2AL3

Histone H2A-like 3

Also known as: H2A.L.3, H2AL1RP, H2AL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A3B3IU63
Gene
H2AL3
Ensembl
ENSG00000229674
Chromosome
X
Canonical length
148 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>A0A3B3IU63|H2AL3
     1  MAGNKMFCRP RRQRLSHSRR AELQFPVSHL ERCLRESQHA RHLSSTTPVF LAGVLEYLTA
    61  NILEKVGKEV KNSCRLCITP EHVKRALQKD EQLRWILELE DDTHSQVEEM PQSEEEEEEE
   121  EEKEEEMVVL VVMGGRRRRR RRRRRKDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.2 nTPM
  • retina: 0.3 nTPM
  • skeletal muscle: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • adrenal gland: 0.1 nTPM

Single-cell type

  • late spermatids: 115 nCPM
  • early spermatids: 22 nCPM
  • late primary spermatocytes: 3.5 nCPM
  • goblet cells: 1.3 nCPM
  • neuroendocrine cells: 0.5 nCPM
  • colonocytes: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 4.3 nTPM
  • hypothalamus: 4.2 nTPM
  • hippocampal formation: 3.2 nTPM
  • amygdala: 2.9 nTPM
  • cerebral cortex: 2.9 nTPM
  • thalamus: 2.6 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AL3 as an antibody target. Whether an autoantibody or antibody against H2AL3 could matter depends on whether native H2AL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2AL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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