Seroatlas · Human Serome Atlas

H2AB1

Histone H2A-Bbd type 1

Also known as: H2A.B.2, H2AB1_HUMAN, H2AFB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C5Y9
Gene
H2AB1
Ensembl
ENSG00000274183
Chromosome
X
Canonical length
115 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P0C5Y9|H2AB1
     1  MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR TAPVYLAAVI
    61  EYLTAKVPEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST LFNTTTISQV APGED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • bone marrow: 0.6 nTPM
  • duodenum: 0.4 nTPM
  • kidney: 0.4 nTPM
  • skeletal muscle: 0.4 nTPM
  • skin: 0.3 nTPM

Single-cell type

  • late spermatids: 65 nCPM
  • early spermatids: 20 nCPM
  • late primary spermatocytes: 18 nCPM
  • adrenal medulla cells: 11 nCPM
  • early primary spermatocytes: 1.1 nCPM
  • undifferentiated spermatogonia: 0.7 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • midbrain: 0.5 nTPM
  • pons: 0.5 nTPM
  • amygdala: 0.4 nTPM
  • hippocampal formation: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2AB1.

Disease | ImmuneIEDB

Conditions an epitope on H2AB1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AB1 as an antibody target. Whether an autoantibody or antibody against H2AB1 could matter depends on whether native H2AB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2AB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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