Seroatlas · Human Serome Atlas

H1-7

Testis-specific H1 histone

Also known as: H1FNT, H1FNT_HUMAN, H1T2, HANP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q75WM6
Gene
H1-7
Ensembl
ENSG00000187166
Chromosome
12
Canonical length
255 aa
Protein class
Predicted intracellular proteins
Subcellular location
Perinuclear theca,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q75WM6|H1-7
     1  MEQALTGEAQ SRWPRRGGSG AMAEAPGPSG ESRGHSATQL PAEKTVGGPS RGCSSSVLRV
    61  SQLVLQAIST HKGLTLAALK KELRNAGYEV RRKSGRHEAP RGQAKATLLR VSGSDAAGYF
   121  RVWKVPKPRR KPGRARQEEG TRAPWRTPAA PRSSRRRRQP LRKAARKARE VWRRNARAKA
   181  KANARARRTR RARPRAKEPP CARAKEEAGA TAADEGRGQA VKEDTTPRSG KDKRRSSKPR
   241  EEKQEPKKPA QRTIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H1-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
208 nTPM

Expression across tissuesHPA

Tissue

  • testis: 208 nTPM
  • cerebellum: 0.7 nTPM
  • ovary: 0.7 nTPM
  • cerebral cortex: 0.5 nTPM
  • adrenal gland: 0.4 nTPM
  • colon: 0.4 nTPM

Single-cell type

  • late spermatids: 7,369 nCPM
  • early spermatids: 2,080 nCPM
  • late primary spermatocytes: 666 nCPM
  • leydig cells: 12 nCPM
  • sertoli cells: 11 nCPM
  • undifferentiated spermatogonia: 7.1 nCPM

Immune cell

  • MAIT T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 1.5 nTPM
  • white matter: 1.3 nTPM
  • medulla oblongata: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • basal ganglia: 1.1 nTPM
  • hippocampal formation: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0
gnomAD pLI
0
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H1-7 as an antibody target. Whether an autoantibody or antibody against H1-7 could matter depends on whether native H1-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H1-7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H1-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H1-7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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