Seroatlas · Human Serome Atlas

GZMB

Granzyme B

Also known as: CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, GRAB_HUMAN, HLP, SECT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10144
Gene: GZMB
Ensembl: ENSG00000100453
Chromosome: 14
Canonical length: 247 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Calyx
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>P10144|GZMB
     1  MQPILLLLAF LLLPRADAGE IIGGHEAKPH SRPYMAYLMI WDQKSLKRCG GFLIRDDFVL
    61  TAAHCWGSSI NVTLGAHNIK EQEPTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKR
   121  TRAVQPLRLP SNKAQVKPGQ TCSVAGWGQT APLGKHSHTL QEVKMTVQED RKCESDLRHY
   181  YDSTIELCVG DPEIKKTSFK GDSGGPLVCN KVAQGIVSYG RNNGMPPRAC TKVSSFVHWI
   241  KKTMKRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GZMB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 63 nTPM
lymph node: 34 nTPM
tonsil: 32 nTPM
spleen: 27 nTPM
urinary bladder: 17 nTPM
appendix: 17 nTPM

Single-cell type

pdcs: 1,959 nCPM
nk-cells: 795 nCPM
t-cells: 186 nCPM
thymocytes: 14 nCPM
innate lymphoid cells: 12 nCPM
plasma cells: 9.3 nCPM

Immune cell

plasmacytoid DC: 6,751 nTPM
total PBMC: 1,603 nTPM
gdT-cell: 1,337 nTPM
memory CD8 T-cell: 640 nTPM
naive CD8 T-cell: 608 nTPM
NK-cell: 508 nTPM

Brain region

hypothalamus: 14 nTPM
thalamus: 1.5 nTPM
pons: 1.1 nTPM
midbrain: 1 nTPM
medulla oblongata: 0.9 nTPM
choroid plexus: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.31
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GZMB as an antibody target. Whether an autoantibody or antibody against GZMB could matter depends on whether native GZMB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GZMB is annotated as secreted, so native GZMB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GZMB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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