GYPE
Glycophorin-E
Also known as: GLPE_HUMAN, GPE, MNS
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P15421
- Gene
- GYPE
- Ensembl
- ENSG00000197465
- Chromosome
- 4
- Canonical length
- 78 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
78 residues, UniProt reviewed canonical sequence.
>P15421|GYPE
1 MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI NWWAMARVIF
61 EVMLVVVGMI ILISYCIRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GYPE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 13 nTPM
- spleen: 3 nTPM
- lung: 2.7 nTPM
- tonsil: 2.4 nTPM
- blood vessel: 1.7 nTPM
- adipose tissue: 1.4 nTPM
Single-cell type
- erythrocyte progenitors: 74 nCPM
- cardiomyocytes: 43 nCPM
- epicardial cells: 27 nCPM
- thymocytes: 24 nCPM
- erythrocytes: 20 nCPM
- adipocytes: 16 nCPM
Immune cell
- memory B-cell: 1.2 nTPM
- NK-cell: 0.5 nTPM
- MAIT T-cell: 0.3 nTPM
- naive B-cell: 0.2 nTPM
- naive CD4 T-cell: 0.2 nTPM
- naive CD8 T-cell: 0.1 nTPM
Brain region
- cerebral cortex: 7.6 nTPM
- basal ganglia: 5.9 nTPM
- white matter: 4.7 nTPM
- amygdala: 3.9 nTPM
- hippocampal formation: 3.5 nTPM
- pons: 2.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.62
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.22
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GYPE as an antibody target. Whether an autoantibody or antibody against GYPE could matter depends on whether native GYPE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GYPE is annotated at the cell surface, where native GYPE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GYPE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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