Seroatlas · Human Serome Atlas

GYPC

Glycophorin-C

Also known as: CD236, CD236R, Ge, GLPC_HUMAN, GPC, GYPD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P04921
Gene: GYPC
Ensembl: ENSG00000136732
Chromosome: 2
Canonical length: 128 aa
Protein class: Blood group antigen proteins, CD markers, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>P04921|GYPC
     1  MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME TSTPTIMDIV
    61  VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE FAESADAALQ GDPALQDAGD
   121  SSRKEYFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GYPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 416 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 416 nTPM
skeletal muscle: 199 nTPM
tongue: 190 nTPM
heart muscle: 175 nTPM
adipose tissue: 163 nTPM
breast: 125 nTPM

Single-cell type

hofbauer cells: 949 nCPM
erythrocytes: 883 nCPM
erythrocyte progenitors: 731 nCPM
melanocytes: 398 nCPM
lymphatic endothelial cells: 385 nCPM
decidual stromal cells: 281 nCPM

Immune cell

naive CD4 T-cell: 191 nTPM
naive CD8 T-cell: 189 nTPM
memory CD8 T-cell: 187 nTPM
T-reg: 180 nTPM
MAIT T-cell: 173 nTPM
gdT-cell: 153 nTPM

Brain region

white matter: 26 nTPM
thalamus: 23 nTPM
medulla oblongata: 20 nTPM
spinal cord: 17 nTPM
hypothalamus: 17 nTPM
choroid plexus: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GYPC.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 77 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Malaria, resistance to

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.11
gnomAD missense Z: -1.3
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GYPC as an antibody target. Whether an autoantibody or antibody against GYPC could matter depends on whether native GYPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GYPC is annotated at the cell surface, where native GYPC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GYPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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