GYPB

Protein identityUniProt · HPA

UniProt accession

P06028

Gene

GYPB

Ensembl

ENSG00000250361

Chromosome

4

Canonical length

91 aa

Protein class

Blood group antigen proteins, CD markers, Predicted intracellular proteins, Predicted membrane proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>P06028|GYPB
     1  MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ LVHRFTVPAP
    61  VVIILIILCV MAGIIGTILL ISYSIRRLIK A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GYPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

59 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.8

gnomAD pLI

0

gnomAD missense Z

-1.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• ankyrin-1 complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Glycophorin
• Glycophorin, conserved site
• Glycophorin A/B
• Glycophorin A

KeywordsUniProt

• Blood group antigen
• Cell membrane
• Glycoprotein
• Membrane
• Sialic acid
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of GYPB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RHAG