GYPA

Protein identityUniProt · HPA

UniProt accession

P02724

Gene

GYPA

Ensembl

ENSG00000170180

Chromosome

4

Canonical length

150 aa

Protein class

Blood group antigen proteins, CD markers, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>P02724|GYPA
     1  MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNDTHKR DTYAATPRAH
    61  EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM AGVIGTILLI SYGIRRLIKK
   121  SPSDVKPLPS PDTDVPLSSV EIENPETSDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GYPA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

147 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GYPA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 21 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• BLOOD GROUP ERIK

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0

gnomAD missense Z

-0.55

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• identical protein binding
• virus receptor activity

Cellular components

• ankyrin-1 complex
• cytosol
• membrane
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Glycophorin
• Glycophorin, conserved site
• Glycophorin A/B
• Glycophorin A

KeywordsUniProt

• Blood group antigen
• Cell membrane
• Glycoprotein
• Host cell receptor for virus entry
• Host-virus interaction
• Membrane
• Phosphoprotein
• Receptor
• Sialic acid
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of GYPA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SLC4A1