Seroatlas · Human Serome Atlas

GXYLT2

Glucoside xylosyltransferase 2

Also known as: GLT8D4, GXLT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PJZ3
Gene: GXYLT2
Ensembl: ENSG00000172986
Chromosome: 3
Canonical length: 443 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Midbody ring

OverviewNCBI Gene

The protein encoded by this gene is a xylosyltransferase that elongates O-linked glucose bound to epidermal growth factor (EGF) repeats. The encoded protein catalyzes the addition of xylose to the O-glucose-modified residues of EGF repeats of Notch proteins. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>A0PJZ3|GXYLT2
     1  MKLRSKAAAL LLLALAALLL ALLSLRAGRA EPPALPARPA SAPQRHPAPV PARWPGPGAL
    61  PGASPGVRRR RPPRPRPRAG RRGAARLEKL ARRPGEPRSF QAVLPPELWI HLAVVACGNR
   121  LEETLVMLKS AVLFSHRKIQ FHIFTEDSLK PEFDKQLRQW PDSYTKKFEH RIYPITFSVG
   181  NPQEWKKLFK PCAAQRLFLP VILKDVDSLL YVDTDVLFLR PVDDIWKLLR LFNSTQLAAM
   241  APEHEIPKIG WYSRFARHPF YGSAGVNSGV MLMNLTRIRS TQFKNSMIPT GLAWEDMLYP
   301  LYQKYKNAIT WGDQDLLNII FYFNPECLYV FPCQWNYRPD HCMYGSNCRE AEHEGVSVLH
   361  GNRGVYHDDK QPTFRALYEA IRDFPFQDNL FQSMYYPLQL KFLETVHTLC GRIPQVFLKQ
   421  IEKTMKRAYE KHVIIHVGPN QMH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GXYLT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

ovary: 14 nTPM
heart muscle: 13 nTPM
blood vessel: 11 nTPM
gallbladder: 9.5 nTPM
thyroid gland: 8.2 nTPM
thymus: 6.2 nTPM

Single-cell type

myosatellite cells: 203 nCPM
mesothelial cells: 189 nCPM
medullary thymic epithelial cells: 120 nCPM
endometrial stromal cells: 115 nCPM
fibro-adipogenic progenitors: 112 nCPM
fibroblasts: 88 nCPM

Immune cell

plasmacytoid DC: 0.6 nTPM
neutrophil: 0.3 nTPM
T-reg: 0.3 nTPM
basophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

white matter: 18 nTPM
medulla oblongata: 17 nTPM
midbrain: 16 nTPM
spinal cord: 15 nTPM
basal ganglia: 15 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GXYLT2 as an antibody target. Whether an autoantibody or antibody against GXYLT2 could matter depends on whether native GXYLT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GXYLT2 is annotated at the cell surface, where native GXYLT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GXYLT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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