Seroatlas · Human Serome Atlas

GXYLT1

Glucoside xylosyltransferase 1

Also known as: FLJ43151, GLT8D3, GXLT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4G148
Gene: GXYLT1
Ensembl: ENSG00000151233
Chromosome: 12
Canonical length: 440 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2010]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q4G148|GXYLT1
     1  MRRYLRVVVL CVACGFCSLL YAFSQLAVSL EEGTGGGGGK PQAAVASWLA GGGRGAVRGA
    61  GVAGPAAHPG VSDRCKDFSL CYWNPYWMLP SDVCGMNCFW EAAFRYSLKI QPVEKMHLAV
   121  VACGERLEET MTMLKSAIIF SIKPLQFHIF AEDQLHHSFK GRLDNWSFLQ TFNYTLYPIT
   181  FPSENAAEWK KLFKPCASQR LFLPLILKEV DSLLYVDTDI LFLRPVDDIW SLLKKFNSTQ
   241  IAAMAPEHEE PRIGWYNRFA RHPYYGKTGV NSGVMLMNMT RMRRKYFKND MTTVRLQWGD
   301  ILMPLLKKYK LNITWGDQDL LNIVFFHNPE SLFVFPCQWN YRPDHCIYGS NCQEAEEGGI
   361  FILHGNRGVY HDDKQPAFRA VYEALRNCSF EDDNIRSLLK PLELELQKTV HTYCGKIYKI
   421  FIKQLAKSVR DRYARSPKEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GXYLT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

liver: 12 nTPM
placenta: 10 nTPM
testis: 8.9 nTPM
thyroid gland: 8.3 nTPM
bone marrow: 7.1 nTPM
thymus: 6.4 nTPM

Single-cell type

sertoli cells: 95 nCPM
cytotrophoblasts: 78 nCPM
rod photoreceptor cells: 75 nCPM
neutrophil progenitors: 75 nCPM
syncytiotrophoblasts: 73 nCPM
gonadotrophs: 69 nCPM

Immune cell

eosinophil: 1.8 nTPM
non-classical monocyte: 1.5 nTPM
intermediate monocyte: 1.2 nTPM
myeloid DC: 1 nTPM
NK-cell: 0.9 nTPM
T-reg: 0.7 nTPM

Brain region

hypothalamus: 14 nTPM
spinal cord: 12 nTPM
medulla oblongata: 12 nTPM
white matter: 11 nTPM
midbrain: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.13
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GXYLT1 as an antibody target. Whether an autoantibody or antibody against GXYLT1 could matter depends on whether native GXYLT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GXYLT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GXYLT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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