Seroatlas · Human Serome Atlas

GVQW3

Protein GVQW3

Also known as: GVQW3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3ZCU0
Gene
GVQW3
Ensembl
ENSG00000179240
Chromosome
11
Canonical length
254 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Centrosome,Cytosol

OverviewNCBI Gene

No narrative summary is available for GVQW3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q3ZCU0|GVQW3
     1  MSDRYLEQRI SIKFCVKLNK SASETHHLLK EAYGDEVMSR ARVFDWHKRF KEGREDVRDD
    61  ARSGRPVTHR TDDNIQKVKD LVCSNRQLTV RMMAEELNLD KETVRLILKE NLNMRKISAK
   121  VISGVLKETE PHYVAQAGLE LLVSRDPPTL ASQSSGIISM SHHAKPKPGV QWCKFQSEST
   181  GRRARSADVQ GQEKMDVTAQ EARTNLPFYL FVLFRSSMNW MMSMHIREGC LFITRSTNSN
   241  ANLFRKHPHR HTQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GVQW3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • retina: 13 nTPM
  • pancreas: 4.6 nTPM
  • cerebellum: 2.5 nTPM
  • cerebral cortex: 2.5 nTPM
  • pituitary gland: 2.4 nTPM
  • thymus: 2.2 nTPM

Single-cell type

  • rod photoreceptor cells: 36 nCPM
  • adrenal medulla cells: 32 nCPM
  • brain excitatory neurons: 31 nCPM
  • brain inhibitory neurons: 30 nCPM
  • ependymal cells: 28 nCPM
  • retinal horizontal cells: 26 nCPM

Immune cell

  • basophil: 1.4 nTPM
  • neutrophil: 1 nTPM
  • NK-cell: 0.8 nTPM
  • T-reg: 0.7 nTPM
  • naive B-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.6 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebellum: 16 nTPM
  • cerebral cortex: 13 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 12 nTPM
  • hypothalamus: 11 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GVQW3 as an antibody target. Whether an autoantibody or antibody against GVQW3 could matter depends on whether native GVQW3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GVQW3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GVQW3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GVQW3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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