Seroatlas · Human Serome Atlas

GUSBP1

Putative inactive beta-glucuronidase-like protein SMA3

Also known as: GUSP1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15486
Gene: GUSBP1
Canonical length: 140 aa

OverviewNCBI Gene

No narrative summary is available for GUSBP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q15486|GUSBP1
     1  MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG TQGQLKVLGA
    61  NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL HLRSRQGGSV CGCDPCEQLL
   121  LLVSQLRAPG VDSAAAGRPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GUSBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GUSBP1 as an antibody target. Whether an autoantibody or antibody against GUSBP1 could matter depends on whether native GUSBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GUSBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GUSBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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