Seroatlas · Human Serome Atlas

GUCY1B2

Guanylate cyclase soluble subunit beta-2

Also known as: GCYB2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75343
Gene: GUCY1B2
Canonical length: 617 aa

OverviewNCBI Gene

No narrative summary is available for GUCY1B2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>O75343|GUCY1B2
     1  MSGYDRMLRT LGGNLMEFIE NLDALHSYLA LSYQEMNAPS FRVERGADGK MFLHYYSDRS
    61  GLCHIVPGII EAVAKDFFDI DVIMDILDMN EEVERTGKKE HVVFLIVQKA HRKMRKTKPK
   121  RLQDSQGMER DQEALQAAFL KMKEKYLNVS ACPVKKSHWD VVRSIVMFGK GHLMNTFEPI
   181  YPERLWIEEK TFCNAFPFHI VFDESLQVKQ ARVNIQKYVP GLQTQNIQLD EYFSIIHPQV
   241  TFNIFSIRRF INSQFVLKTR REMMPVAWQS RTTLKLQGQM IWMESMWCMV YLCSPKLRSL
   301  QELEELNMHL SDIAPNDTTR DLILLNQQRL AEIELSNQLE RKKEELQVLS KHLAIEKKKT
   361  ETLLYAMLPK HVANQLREGK KVAAGEFKSC TILFSDVVTF TNICTACEPI QIVNVLNSMY
   421  SKFDRLTSVH AVYKVETIGD AYMVVGGVPV PIGNHAQRVA NFALGMRISA KEVTNPVTGE
   481  PIQLRVGIHT GPVLADVVGD KMPRYCLFGD TVNTASRMES HGLPNKVHLS PTAYRALKNQ
   541  GFKIIERGEI EVKGKGRMTT YFLIQNLNAT EDEIMGRSKT PVDHKGSTQK ASLPTTKLQG
   601  SVQPSCPEHS SLASWLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GUCY1B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GUCY1B2 as an antibody target. Whether an autoantibody or antibody against GUCY1B2 could matter depends on whether native GUCY1B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GUCY1B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GUCY1B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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