Seroatlas · Human Serome Atlas

GUCY1A1

Guanylate cyclase soluble subunit alpha-1

Also known as: GC-SA3, GCYA1_HUMAN, GUC1A3, GUCY1A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02108
Gene
GUCY1A1
Ensembl
ENSG00000164116
Chromosome
4
Canonical length
690 aa
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>Q02108|GUCY1A1
     1  MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP
    61  QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE
   121  QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG
   181  KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF
   241  HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ
   301  FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS
   361  SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR
   421  AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV
   481  TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK
   541  ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN
   601  VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY
   661  QQGTNSKPCF QKKDVEDGNA NFLGKASGID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GUCY1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 32 nTPM
  • parathyroid gland: 30 nTPM
  • smooth muscle: 27 nTPM
  • colon: 25 nTPM
  • placenta: 24 nTPM
  • prostate: 24 nTPM

Single-cell type

  • prostatic glandular cells: 550 nCPM
  • hematopoietic stem cells: 539 nCPM
  • vascular smooth muscle cells: 367 nCPM
  • pericytes: 288 nCPM
  • retinal bipolar cells: 281 nCPM
  • thymocytes: 219 nCPM

Immune cell

  • plasmacytoid DC: 12 nTPM
  • non-classical monocyte: 10 nTPM
  • NK-cell: 8.3 nTPM
  • myeloid DC: 2.5 nTPM
  • intermediate monocyte: 2.3 nTPM
  • total PBMC: 1 nTPM

Brain region

  • basal ganglia: 67 nTPM
  • cerebral cortex: 46 nTPM
  • thalamus: 39 nTPM
  • midbrain: 38 nTPM
  • amygdala: 38 nTPM
  • hippocampal formation: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GUCY1A1.

Disease | AllUniProt

Conditions GUCY1A1 is implicated in, by any mechanism.

  • Moyamoya disease 6 with or without achalasia (MYMY6) MIM:615750

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 185 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GUCY1A1 as an antibody target. Whether an autoantibody or antibody against GUCY1A1 could matter depends on whether native GUCY1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GUCY1A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GUCY1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GUCY1A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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