Seroatlas · Human Serome Atlas

GUCD1

Protein GUCD1

Also known as: C22orf13, GUCD1_HUMAN, LLN4, MGC1842

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NT3
Gene
GUCD1
Ensembl
ENSG00000138867
Chromosome
22
Canonical length
240 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in liver regeneration and response to cAMP. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q96NT3|GUCD1
     1  MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD SEFERALQKL
    61  QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF YRKHFDTEET RVNQLFAQAK
   121  ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT
   181  PDYQGHFIVL RGYNRATGCI FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GUCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 110 nTPM
  • liver: 95 nTPM
  • skeletal muscle: 91 nTPM
  • bone marrow: 85 nTPM
  • duodenum: 64 nTPM
  • heart muscle: 62 nTPM

Single-cell type

  • hepatocytes: 196 nCPM
  • enterocytes: 155 nCPM
  • erythrocyte progenitors: 90 nCPM
  • cholangiocytes: 84 nCPM
  • colonocytes: 77 nCPM
  • goblet cells: 68 nCPM

Immune cell

  • eosinophil: 53 nTPM
  • naive B-cell: 43 nTPM
  • memory B-cell: 37 nTPM
  • basophil: 20 nTPM
  • neutrophil: 15 nTPM
  • classical monocyte: 15 nTPM

Brain region

  • thalamus: 37 nTPM
  • medulla oblongata: 36 nTPM
  • midbrain: 36 nTPM
  • spinal cord: 34 nTPM
  • basal ganglia: 33 nTPM
  • white matter: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.24
gnomAD missense Z
0.89
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

  • Protein GUCD1
  • Guanylylate cyclase

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GUCD1 as an antibody target. Whether an autoantibody or antibody against GUCD1 could matter depends on whether native GUCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GUCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GUCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GUCD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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