GUCA2B
Guanylate cyclase activator 2B
Also known as: GUC2B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q16661
- Gene
- GUCA2B
- Ensembl
- ENSG00000044012
- Chromosome
- 1
- Canonical length
- 112 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]
Canonical amino-acid sequenceUniProt
112 residues, UniProt reviewed canonical sequence.
>Q16661|GUCA2B
1 MGCRAASGLL PGVAVVLLLL LQSTQSVYIQ YQGFRVQLES MKKLSDLEAQ WAPSPRLQAQ
61 SLLPAVCHHP ALPQDLQPVC ASQEASSIFK TLRTIANDDC ELCVNVACTG CLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GUCA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 138 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 138 nTPM
- colon: 84 nTPM
- duodenum: 34 nTPM
- rectum: 22 nTPM
- stomach: 17 nTPM
- liver: 5.4 nTPM
Single-cell type
- enterocytes: 3,100 nCPM
- colonocytes: 1,493 nCPM
- parietal cells: 290 nCPM
- goblet cells: 95 nCPM
- paneth cells: 74 nCPM
- neuroendocrine cells: 47 nCPM
Immune cell
- intermediate monocyte: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0.38
- gnomAD missense Z
- 0.32
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adipose tissue development
- body fluid secretion
- cGMP-mediated signaling
- glucose homeostasis
- multicellular organism growth
- negative regulation of blood pressure
- reduction of food intake in response to dietary excess
- renal sodium ion absorption
- response to glucose
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GUCA2B as an antibody target. Whether an autoantibody or antibody against GUCA2B could matter depends on whether native GUCA2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GUCA2B is annotated as secreted, so native GUCA2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label GUCA2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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