GUCA2A
Guanylin
Also known as: GUC2A_HUMAN, GUCA2, STARA
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q02747
- Gene
- GUCA2A
- Ensembl
- ENSG00000197273
- Chromosome
- 1
- Canonical length
- 115 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Predicted to enable guanylate cyclase activator activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>Q02747|GUCA2A
1 MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV GKLRNFAPIP
61 GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED PGTCEICAYA ACTGCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GUCA2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 969 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 969 nTPM
- rectum: 680 nTPM
- colon: 671 nTPM
- duodenum: 53 nTPM
- smooth muscle: 16 nTPM
- placenta: 6.8 nTPM
Single-cell type
- enterocytes: 12,562 nCPM
- colonocytes: 5,337 nCPM
- paneth cells: 1,037 nCPM
- goblet cells: 327 nCPM
- enteric transient amplifying cells: 129 nCPM
- neuroendocrine cells: 120 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- pons: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0.29
- gnomAD missense Z
- -1.07
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GUCA2A as an antibody target. Whether an autoantibody or antibody against GUCA2A could matter depends on whether native GUCA2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GUCA2A is annotated as secreted, so native GUCA2A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label GUCA2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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