Seroatlas · Human Serome Atlas

GTSF1L

Gametocyte-specific factor 1-like

Also known as: C20orf65, dJ1028D15.4, FAM112A, GTSFL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H1H1
Gene
GTSF1L
Ensembl
ENSG00000124196
Chromosome
20
Canonical length
148 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q9H1H1|GTSF1L
     1  MEPEAFEICP YDPHHRIPLS RFQYHLASCR RKNPKKAKKM ATCKYNACHV VPIKNLEEHE
    61  AVCVNRSAVE EEDTENPLKV SPPSSEQNDD TQQVSPCLPS PDIWNVDGAN CQHVFVLKTF
   121  FPQKVVCEND TKESARETSP QKILRPGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTSF1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
211 nTPM

Expression across tissuesHPA

Tissue

  • testis: 211 nTPM
  • lymph node: 1.4 nTPM
  • tonsil: 1.1 nTPM
  • spleen: 0.7 nTPM
  • appendix: 0.3 nTPM
  • small intestine: 0.3 nTPM

Single-cell type

  • late spermatids: 5,894 nCPM
  • early spermatids: 3,313 nCPM
  • late primary spermatocytes: 746 nCPM
  • sertoli cells: 19 nCPM
  • leydig cells: 8.4 nCPM
  • peritubular myoid cells: 6.2 nCPM

Immune cell

  • T-reg: 4 nTPM
  • memory B-cell: 0.8 nTPM
  • naive B-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTSF1L as an antibody target. Whether an autoantibody or antibody against GTSF1L could matter depends on whether native GTSF1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTSF1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTSF1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GTSF1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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