Seroatlas · Human Serome Atlas

GTSF1

Gametocyte-specific factor 1

Also known as: Cue110, FAM112B, FLJ32942, GTSF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW33
Gene: GTSF1
Ensembl: ENSG00000170627
Chromosome: 12
Canonical length: 167 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables tRNA binding activity. Predicted to be involved in piRNA-mediated gene silencing by mRNA destabilization and secondary piRNA processing. Predicted to be located in cytoplasm. Predicted to be active in piP-body. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q8WW33|GTSF1
     1  MEETYTDSLD PEKLLQCPYD KNHQIRACRF PYHLIKCRKN HPDVASKLAT CPFNARHQVP
    61  RAEISHHISS CDDRSCIEQD VVNQTRSLRQ ETLAESTWQC PPCDEDWDKD LWEQTSTPFV
   121  WGTTHYSDNN SPASNIVTEH KNNLASGMRV PKSLPYVLPW KNNGNAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTSF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 174 nTPM

Expression across tissuesHPA

Tissue

testis: 174 nTPM
placenta: 13 nTPM
tonsil: 10 nTPM
bone marrow: 5.7 nTPM
thymus: 5.6 nTPM
lymph node: 5.2 nTPM

Single-cell type

late spermatids: 2,935 nCPM
late primary spermatocytes: 1,287 nCPM
early spermatids: 1,128 nCPM
oocytes: 764 nCPM
early primary spermatocytes: 226 nCPM
extravillous trophoblasts: 151 nCPM

Immune cell

naive B-cell: 34 nTPM
plasmacytoid DC: 34 nTPM
memory B-cell: 34 nTPM
memory CD8 T-cell: 33 nTPM
NK-cell: 32 nTPM
T-reg: 31 nTPM

Brain region

white matter: 2.7 nTPM
cerebral cortex: 2.4 nTPM
medulla oblongata: 2.4 nTPM
thalamus: 2.4 nTPM
pons: 2.2 nTPM
basal ganglia: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GTSF1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 22 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.02
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

piP-body

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTSF1 as an antibody target. Whether an autoantibody or antibody against GTSF1 could matter depends on whether native GTSF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTSF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTSF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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