GTF3A

Protein identityUniProt · HPA

UniProt accession

Q92664

Gene

GTF3A

Ensembl

ENSG00000122034

Chromosome

13

Canonical length

365 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q92664|GTF3A
     1  MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN YSKAWKLDAH
    61  LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF VCAANGCDQK FNTKSNLKKH
   121  FERKHENQQK QYICSFEDCK KTFKKHQQLK IHQCQHTNEP LFKCTQEGCG KHFASPSKLK
   181  RHAKAHEGYV CQKGCSFVAK TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA
   241  PERDVCRCPR EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV
   301  HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC VEDKMLSTVA
   361  VLTLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

151 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.6

gnomAD pLI

0

gnomAD missense Z

-0.14

DepMap mean gene effect

-1.1

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ribosomal large subunit biogenesis
• rRNA transcription
• transcription by RNA polymerase III

Molecular functions

• 5S rRNA binding
• DNA binding
• zinc ion binding

Cellular components

• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• Transcription factor IIIA, beta-beta-alpha zinc finger
• TFIIIA, beta-beta-alpha zinc finger

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Ribosome biogenesis
• RNA-binding
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of GTF3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

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