Seroatlas · Human Serome Atlas

GTDC1

tRNA-queuosine alpha-mannosyltransferase

Also known as: FLJ11753, Hmat-Xa, QTMAN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4AE62
Gene: GTDC1
Ensembl: ENSG00000121964
Chromosome: 2
Canonical length: 458 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables tRNA-queuosine(34) beta-mannosyltransferase activity. Involved in regulation of translation and tRNA modification. Located in nucleus. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q4AE62|GTDC1
     1  MSILIIEAFY GGSHKQLVDL LQEELGDCVV YTLPAKKWHW RARTSALYFS QTIPISEHYR
    61  TLFASSVLNL TELAALRPDL GKLKKILYFH ENQLIYPVKK CQERDFQYGY NQILSCLVAD
   121  VVVFNSVFNM ESFLTSMGKF MKLIPDHRPK DLESIIRPKC QVIYFPIRFP DVSRFMPKHK
   181  TTHLKKMLGL KGNGGAVLSM ALPFQPEQRD SEDLLKNFNS ECDTHCGLDT ARQEYLGNSL
   241  RQESDLKKST SSDNSSSHHG ENKQNLTVDP CDILGGVDNQ QRLLHIVWPH RWEHDKDPES
   301  FFKVLMHLKD LGLNFHVSVL GETFTDVPDI FSEAKKALGS SVLHWGYLPS KDDYFQVLCM
   361  ADVVISTAKH EFFGVAMLEA VYCGCYPLCP KDLVYPEIFP AEYLYSTPEQ LSKRLQNFCK
   421  RPDIIRKHLY KGEIAPFSWA ALHGKFRSLL TTEPREDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 18 nTPM
cerebral cortex: 17 nTPM
heart muscle: 16 nTPM
adipose tissue: 15 nTPM
amygdala: 15 nTPM
bone marrow: 15 nTPM

Single-cell type

neutrophils: 1,273 nCPM
neutrophil progenitors: 506 nCPM
oligodendrocytes: 448 nCPM
podocytes: 351 nCPM
oligodendrocyte progenitor cells: 295 nCPM
myosatellite cells: 255 nCPM

Immune cell

MAIT T-cell: 16 nTPM
neutrophil: 14 nTPM
memory CD8 T-cell: 12 nTPM
NK-cell: 12 nTPM
eosinophil: 10 nTPM
gdT-cell: 7.5 nTPM

Brain region

white matter: 58 nTPM
cerebral cortex: 50 nTPM
spinal cord: 44 nTPM
basal ganglia: 43 nTPM
hippocampal formation: 41 nTPM
amygdala: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.02
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

tRNA-queuosine(34) beta-mannosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glycosyl transferase, family 1
Glycosyl transferases group 1
tRNA-queuosine alpha-mannosyltransferase, N-terminal
Glycosyltransferase-like domain-containing protein 1
tRNA-queuosine alpha-mannosyltransferase N-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTDC1 as an antibody target. Whether an autoantibody or antibody against GTDC1 could matter depends on whether native GTDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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