Seroatlas · Human Serome Atlas

GSX1

GS homeobox 1

Also known as: Gsh-1, GSH1, GSX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4S2
Gene: GSX1
Ensembl: ENSG00000169840
Chromosome: 13
Canonical length: 264 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q9H4S2|GSX1
     1  MPRSFLVDSL VLREAGEKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR KAGLLCVCPL
    61  CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS AVSPGVAHGP AAAAAAAALY
   121  QTSYPLPDPR QFHCISVDSS SNQLPSSKRM RTAFTSTQLL ELEREFASNM YLSRLRRIEI
   181  ATYLNLSEKQ VKIWFQNRRV KHKKEGKGSN HRGGGGGGAG GGGSAPQGCK CASLSSAKCS
   241  EDDDELPMSP SSSGKDDRDL TVTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 2.4 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
hippocampal formation: 0.2 nTPM
midbrain: 0.1 nTPM

Single-cell type

oligodendrocyte progenitor cells: 0.5 nCPM
other brain neurons: 0.5 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 16 nTPM
thalamus: 0.8 nTPM
basal ganglia: 0.7 nTPM
medulla oblongata: 0.5 nTPM
amygdala: 0.4 nTPM
cerebral cortex: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.04
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSX1 as an antibody target. Whether an autoantibody or antibody against GSX1 could matter depends on whether native GSX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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