Seroatlas · Human Serome Atlas

GSG1L2

Germ cell-specific gene 1-like protein 2

Also known as: GS1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MUP6
Gene
GSG1L2
Ensembl
ENSG00000214978
Chromosome
17
Canonical length
293 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>A8MUP6|GSG1L2
     1  MDRAKQQQAL LLLPVCLALT FSLTAVVSSH WCEGTRRVVK PLCQDQPGGQ HCIHFKRDNS
    61  SNGRMDNNSQ AVLYIWELGD DKFIQRGFHV GLWQSCEESL NGEDEKCRSF RSVVPAEEQG
   121  VLWLSIGGEV LDIVLILTSA ILLGSRVSCR SPGFHWLRVD ALVAIFMVLA GLLGMVAHMM
   181  YTTIFQITVN LGPEDWKPQT WDYGWSYCLA WGSFALCLAV SVSAMSRFTA ARLEFTEKQQ
   241  AQNGSRHSQH SFLEPEASES IWKTGAAPCP AEQAFRNVSG HLPPGAPGKV SIC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSG1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.8 nTPM
  • cerebral cortex: 0.5 nTPM
  • testis: 0.5 nTPM
  • bone marrow: 0.4 nTPM
  • thymus: 0.3 nTPM
  • lymph node: 0.2 nTPM

Single-cell type

  • retinal bipolar cells: 4.3 nCPM
  • early spermatids: 0.9 nCPM
  • renal connecting tubule cells: 0.7 nCPM
  • distal convoluted tubule cells: 0.6 nCPM
  • neuroendocrine cells: 0.5 nCPM
  • podocytes: 0.5 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebellum: 5 nTPM
  • basal ganglia: 3 nTPM
  • cerebral cortex: 3 nTPM
  • white matter: 2.8 nTPM
  • amygdala: 2.7 nTPM
  • hippocampal formation: 2.5 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSG1L2 as an antibody target. Whether an autoantibody or antibody against GSG1L2 could matter depends on whether native GSG1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSG1L2 is annotated at the cell surface, where native GSG1L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSG1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GSG1L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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