Seroatlas · Human Serome Atlas

GSG1L

Germ cell-specific gene 1-like protein

Also known as: GSG1L_HUMAN, KTSR5831, MGC18079, PRO19651

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXU4
Gene: GSG1L
Ensembl: ENSG00000169181
Chromosome: 16
Canonical length: 331 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in regulation of postsynaptic neurotransmitter receptor internalization. Predicted to act upstream of or within several processes, including regulation of AMPA receptor activity; regulation of short-term neuronal synaptic plasticity; and transmission of nerve impulse. Predicted to be located in asymmetric synapse and membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q6UXU4|GSG1L
     1  MKTSRRGRAL LAVALNLLAL LFATTAFLTT HWCQGTQRVP KPGCGQGGRA NCPNSGANAT
    61  ANGTAAPAAA AAAATASGNG PPGGALYSWE TGDDRFLFRN FHTGIWYSCE EELSGLGEKC
   121  RSFIDLAPAS EKGVLWLSVV SEVLYILLLV VGFSLMCLEL FHSSNVIDGL KLNAFAAVFT
   181  VLSGLLGMVA HMMYTQVFQV TVSLGPEDWR PHSWDYGWSF CLAWGSFTCC MAASVTTLNS
   241  YTKTVIEFRH KRKVFEQGYR EEPTFIDPEA IKYFRERMEK RDGSEEDFHL DCRHERYPAR
   301  HQPHMADSWP RSSAQEAPEL NRQCWVLGHW V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSG1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 22 nTPM
basal ganglia: 20 nTPM
blood vessel: 18 nTPM
midbrain: 15 nTPM
amygdala: 14 nTPM
hypothalamus: 10 nTPM

Single-cell type

retinal amacrine cells: 241 nCPM
oligodendrocyte progenitor cells: 203 nCPM
brain inhibitory neurons: 88 nCPM
retinal ganglion cells: 46 nCPM
brain excitatory neurons: 43 nCPM
other brain neurons: 34 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 53 nTPM
thalamus: 43 nTPM
medulla oblongata: 41 nTPM
midbrain: 38 nTPM
pons: 36 nTPM
hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.77
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSG1L as an antibody target. Whether an autoantibody or antibody against GSG1L could matter depends on whether native GSG1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSG1L is annotated at the cell surface, where native GSG1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSG1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...