Seroatlas · Human Serome Atlas

GRPEL2

GrpE protein homolog 2, mitochondrial

Also known as: DKFZp451C205, FLJ23713, GRPE2_HUMAN, Mt-GrpE#2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAA5
Gene: GRPEL2
Ensembl: ENSG00000164284
Chromosome: 5
Canonical length: 225 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q8TAA5|GRPEL2
     1  MAVRSLWAGR LRVQRLLAWS AAWESKGWPL PFSTATQRTA GEDCRSEDPP DELGPPLAER
    61  ALRVKAVKLE KEVQDLTVRY QRAIADCENI RRRTQRCVED AKIFGIQSFC KDLVEVADIL
   121  EKTTECISEE SEPEDQKLTL EKVFRGLLLL EAKLKSVFAK HGLEKLTPIG DKYDPHEHEL
   181  ICHVPAGVGV QPGTVALVRQ DGYKLHGRTI RLARVEVAVE SQRRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRPEL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

esophagus: 43 nTPM
vagina: 11 nTPM
tonsil: 10 nTPM
lung: 10 nTPM
cervix: 9.6 nTPM
heart muscle: 8.8 nTPM

Single-cell type

esophageal apical cells: 1,370 nCPM
late primary spermatocytes: 30 nCPM
esophageal suprabasal cells: 26 nCPM
extravillous trophoblasts: 23 nCPM
lymphatic endothelial cells: 21 nCPM
vascular endothelial cells: 20 nCPM

Immune cell

T-reg: 15 nTPM
basophil: 9.9 nTPM
naive CD4 T-cell: 9.9 nTPM
memory CD4 T-cell: 7.6 nTPM
naive CD8 T-cell: 7.5 nTPM
MAIT T-cell: 6.1 nTPM

Brain region

cerebellum: 20 nTPM
pons: 16 nTPM
hypothalamus: 15 nTPM
thalamus: 15 nTPM
white matter: 14 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRPEL2 as an antibody target. Whether an autoantibody or antibody against GRPEL2 could matter depends on whether native GRPEL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRPEL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRPEL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...