GRK7

Protein identityUniProt · HPA

UniProt accession

Q8WTQ7

Gene

GRK7

Ensembl

ENSG00000114124

Chromosome

3

Canonical length

553 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q8WTQ7|GRK7
     1  MVDMGALDNL IANTAYLQAR KPSDCDSKEL QRRRRSLALP GLQGCAELRQ KLSLNFHSLC
    61  EQQPIGRRLF RDFLATVPTF RKAATFLEDV QNWELAEEGP TKDSALQGLV ATCASAPAPG
   121  NPQPFLSQAV ATKCQAATTE EERVAAVTLA KAEAMAFLQE QPFKDFVTSA FYDKFLQWKL
   181  FEMQPVSDKY FTEFRVLGKG GFGEVCAVQV KNTGKMYACK KLDKKRLKKK GGEKMALLEK
   241  EILEKVSSPF IVSLAYAFES KTHLCLVMSL MNGGDLKFHI YNVGTRGLDM SRVIFYSAQI
   301  ACGMLHLHEL GIVYRDMKPE NVLLDDLGNC RLSDLGLAVE MKGGKPITQR AGTNGYMAPE
   361  ILMEKVSYSY PVDWFAMGCS IYEMVAGRTP FKDYKEKVSK EDLKQRTLQD EVKFQHDNFT
   421  EEAKDICRLF LAKKPEQRLG SREKSDDPRK HHFFKTINFP RLEAGLIEPP FVPDPSVVYA
   481  KDIAEIDDFS EVRGVEFDDK DKQFFKNFAT GAVPIAWQEE IIETGLFEEL NDPNRPTGCE
   541  EGNSSKSGVC LLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

10 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.21

gnomAD pLI

0

gnomAD missense Z

0.96

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein autophosphorylation
• regulation of opsin-mediated signaling pathway
• regulation of signal transduction
• signal transduction
• visual perception

Molecular functions

• ATP binding
• rhodopsin kinase activity

Cellular components

• cytoplasm
• photoreceptor disc membrane

Protein domainsUniProt · Pfam · InterPro

• GPCR kinase
• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• RGS domain
• Protein kinase, ATP binding site
• RGS domain superfamily
• RGS, subdomain 2
• Protein kinase domain
• Regulator of G protein signaling domain

KeywordsUniProt

• ATP-binding
• Kinase
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Phosphoprotein
• Prenylation
• Sensory transduction
• Serine/threonine-protein kinase
• Transferase
• Vision

InteractionsUniProt · HPA

Protein binding partners of GRK7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PDE6D