GRK1

Protein identityUniProt · HPA

UniProt accession

Q15835

Gene

GRK1

Ensembl

ENSG00000185974

Chromosome

13

Canonical length

563 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Principal piece

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q15835|GRK1
     1  MDFGSLETVV ANSAFIAARG SFDGSSSQPS RDKKYLAKLK LPPLSKCESL RDSLSLEFES
    61  VCLEQPIGKK LFQQFLQSAE KHLPALELWK DIEDYDTADN DLQPQKAQTI LAQYLDPQAK
   121  LFCSFLDEGI VAKFKEGPVE IQDGLFQPLL QATLAHLGQA PFQEYLGSLY FLRFLQWKWL
   181  EAQPMGEDWF LDFRVLGKGG FGEVSACQMK ATGKLYACKK LNKKRLKKRK GYQGAMVEKK
   241  ILMKVHSRFI VSLAYAFETK ADLCLVMTIM NGGDIRYHIY NVNEENPGFP EPRALFYTAQ
   301  IICGLEHLHQ RRIVYRDLKP ENVLLDNDGN VRISDLGLAV ELLDGQSKTK GYAGTPGFMA
   361  PELLQGEEYD FSVDYFALGV TLYEMIAARG PFRARGEKVE NKELKHRIIS EPVKYPDKFS
   421  QASKDFCEAL LEKDPEKRLG FRDETCDKLR AHPLFKDLNW RQLEAGMLMP PFIPDSKTVY
   481  AKDIQDVGAF STVKGVAFDK TDTEFFQEFA TGNCPIPWQE EMIETGIFGE LNVWRSDGQM
   541  PDDMKGISGG SSSSSKSGMC LVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

40 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GRK1.

Disease | AllUniProt

Conditions GRK1 is implicated in, by any mechanism.

• Night blindness, congenital stationary, Oguchi type 2 (CSNBO2) MIM:613411

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 106 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Oguchi disease-2
• Retinal dystrophy
• Congenital stationary night blindness

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.82

gnomAD pLI

0

gnomAD missense Z

0.43

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled opsin signaling pathway
• protein autophosphorylation
• regulation of G protein-coupled receptor signaling pathway
• regulation of opsin-mediated signaling pathway
• regulation of signal transduction
• visual perception

Molecular functions

• ATP binding
• protein kinase activity
• rhodopsin kinase activity

Cellular components

• cytoplasm
• photoreceptor disc membrane

Protein domainsUniProt · Pfam · InterPro

• GPCR kinase
• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• RGS domain
• Protein kinase, ATP binding site
• RGS domain superfamily
• RGS, subdomain 2
• Protein kinase domain
• Regulator of G protein signaling domain
• Rhodopsin kinase, catalytic domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Congenital stationary night blindness
• Kinase
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Phosphoprotein
• Prenylation
• Sensory transduction
• Serine/threonine-protein kinase
• Transferase
• Vision

InteractionsUniProt · HPA

Protein binding partners of GRK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RHO