GRHL1

Protein identityUniProt · HPA

UniProt accession

Q9NZI5

Gene

GRHL1

Ensembl

ENSG00000134317

Chromosome

2

Canonical length

618 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

618 residues, UniProt reviewed canonical sequence.

>Q9NZI5|GRHL1
     1  MTQEYDNKRP VLVLQNEALY PQRRSYTSED EAWKSFLENP LTAATKAMMS INGDEDSAAA
    61  LGLLYDYYKV PRERRSSTAK PEVEHPEPDH SKRNSIPIVT EQPLISAGEN RVQVLKNVPF
   121  NIVLPHGNQL GIDKRGHLTA PDTTVTVSIA TMPTHSIKTE TQPHGFAVGI PPAVYHPEPT
   181  ERVVVFDRNL NTDQFSSGAQ APNAQRRTPD STFSETFKEG VQEVFFPSDL SLRMPGMNSE
   241  DYVFDSVSGN NFEYTLEASK SLRQKPGDST MTYLNKGQFY PITLKEVSSS EGIHHPISKV
   301  RSVIMVVFAE DKSREDQLRH WKYWHSRQHT AKQRCIDIAD YKESFNTISN IEEIAYNAIS
   361  FTWDINDEAK VFISVNCLST DFSSQKGVKG LPLNIQVDTY SYNNRSNKPV HRAYCQIKVF
   421  CDKGAERKIR DEERKQSKRK VSDVKVPLLP SHKRMDITVF KPFIDLDTQP VLFIPDVHFA
   481  NLQRGTHVLP IASEELEGEG SVLKRGPYGT EDDFAVPPST KLARIEEPKR VLLYVRKESE
   541  EVFDALMLKT PSLKGLMEAI SDKYDVPHDK IGKIFKKCKK GILVNMDDNI VKHYSNEDTF
   601  QLQIEEAGGS YKLTLTEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRHL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

115 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0.24

gnomAD missense Z

1.68

DepMap mean gene effect

0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• desmosome organization
• epidermis development
• establishment of skin barrier
• positive regulation of transcription by RNA polymerase II
• regulation of DNA-templated transcription
• regulation of keratinocyte differentiation
• regulation of transcription by RNA polymerase II

Molecular functions

• chromatin DNA binding
• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription factor binding
• identical protein binding
• protein homodimerization activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• transcription cis-regulatory region binding

Cellular components

• chromatin
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• CP2 transcription factor
• Transcription factor CP2-like
• GRHL1/CP2, C-terminal domain
• CP2 transcription factor
• GRHL1-like, C-terminal domain

KeywordsUniProt

• Activator
• Developmental protein
• DNA-binding
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation