Seroatlas · Human Serome Atlas

GREP1

Glycine-rich extracellular protein 1

Also known as: GREP1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0J9YXV3
Gene: GREP1
Canonical length: 536 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GREP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>A0A0J9YXV3|GREP1
     1  MGAWAFPAAL FLLCLTSESL QGGLPLLPPG LGKVYGPHSG LGAGYDGGVK PQKPGFVVRH
    61  GLGTQPDTEG GMKPQNLGFR TFAGAAAQPG YGNGLGAAAF PVAGAQSGPA AQNGFGPGFG
   121  GGGKPQKPGP TTQNGYRPGY VGAVKPQKPG FQYRIGLGAQ PGFRGDMKAQ EPGLGNGNGL
   181  SAQPVLTAQN RFGFGAGLGG NVKPLKPGYG KRLRAGAFPG AGTQPEYGHG NGPGVQPGLG
   241  AGMKPQMPGL GAPNGYGPGR GRAGVPGGPE RRPWVPHLLP FSSPGYLGVM KAQKPGPLAQ
   301  NGYRAGAGEG MKPQKPGLRG TLKPQKSGHG HENGPWPGPC NARVAPMLLP RLPTPGVPSD
   361  KEGGWGLKSQ PPSAVQNGKL PAPMPAIQWG LKPQKAGHQP PNGYGPGAEP GFNGGLEPQK
   421  IGLGYGNGVL GARVFPEAHP QPGFHGANGF RNRDGVEALV YPKAAALAPE GNGQAGVLWN
   481  SRWPTLQAWG AGLKPGYQAG DEYAEARSQP GGPDVKRGSN GQLGNGYGGR CPLGKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GREP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.76
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

skin: 3.5 nTPM
thymus: 2.4 nTPM
colon: 0.5 nTPM
salivary gland: 0.4 nTPM
lung: 0.3 nTPM
duodenum: 0.2 nTPM

Single-cell type

medullary thymic epithelial cells: 29 nCPM
esophageal apical cells: 1 nCPM
adipocytes: 0.9 nCPM
cardiomyocytes: 0.8 nCPM
early primary spermatocytes: 0.8 nCPM
suprabasal keratinocytes: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 8.6 nTPM
cerebral cortex: 2.6 nTPM
pons: 2.2 nTPM
hypothalamus: 2.1 nTPM
white matter: 1.9 nTPM
medulla oblongata: 1.8 nTPM

KeywordsUniProt

Signal

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GREP1 as an antibody target. Whether an autoantibody or antibody against GREP1 could matter depends on whether native GREP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GREP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GREP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...