Seroatlas · Human Serome Atlas

GRAMD2B

GRAM domain-containing protein 2B

Also known as: FLJ21313, GRAMD3, GRM2B_HUMAN, NS3TP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HH9
Gene: GRAMD2B
Ensembl: ENSG00000155324
Chromosome: 5
Canonical length: 432 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q96HH9|GRAMD2B
     1  MTELQQDVED TKPAKVLGKR ESKLGSAHSE AENGVEEKKK ACRSPTAQSP TPSVEADSPD
    61  QKKIISLWSK SSFDGASLAS DKNDCKTESK NDPKTERKKS SSSSQYKANM HFHKLFLSVP
   121  TEEPLKQSFT CALQKEILYQ GKLFVSENWI CFHSKVFGKD TKISIPAFSV TLIKKTKTAL
   181  LVPNALIIAT VTDRYIFVSL LSRDSTYKLL KSVCGHLENT SVGNSPNPSS AENSFRADRP
   241  SSLPLDFNDE FSDLDGVVQQ RRQDMEGYSS SGSQTPESEN SRDFHATESQ TVLNVSKGEA
   301  KPTRADAHVN RVPEGKAKSL PVQGLSETVG ILHKVKSQKC PMLHHILIFY AIVVCALIIS
   361  TFYMRYRINT LEEQLGLLTS IVDTHNTEQA APSGLRSQVQ FNVEVLCQEL TANIVKLEKI
   421  QNNLQKLLEN GD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRAMD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 63 nTPM
basal ganglia: 45 nTPM
amygdala: 44 nTPM
thyroid gland: 38 nTPM
breast: 36 nTPM
cerebral cortex: 36 nTPM

Single-cell type

endometrial glandular cells: 902 nCPM
astrocytes: 657 nCPM
ependymal cells: 630 nCPM
epididymal basal cells: 373 nCPM
enterocytes: 361 nCPM
retinal pigment epithelial cells: 358 nCPM

Immune cell

plasmacytoid DC: 4.3 nTPM
naive CD4 T-cell: 3 nTPM
gdT-cell: 2.9 nTPM
MAIT T-cell: 2.9 nTPM
T-reg: 2.4 nTPM
memory CD8 T-cell: 2.3 nTPM

Brain region

spinal cord: 103 nTPM
midbrain: 103 nTPM
medulla oblongata: 96 nTPM
white matter: 90 nTPM
basal ganglia: 84 nTPM
amygdala: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

cytoplasmic microtubule

Protein domainsUniProt · Pfam · InterPro

GRAM domain
PH-like domain superfamily
GRAM domain
GRAM domain-containing protein 2B

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRAMD2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMEM43

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRAMD2B as an antibody target. Whether an autoantibody or antibody against GRAMD2B could matter depends on whether native GRAMD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRAMD2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRAMD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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