Seroatlas · Human Serome Atlas

GPRIN3

G protein-regulated inducer of neurite outgrowth 3

Also known as: FLJ42625, GRIN3, GRIN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVF9
Gene: GPRIN3
Ensembl: ENSG00000185477
Chromosome: 4
Canonical length: 776 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be involved in neuron projection development. Predicted to act upstream of or within several processes, including excitatory chemical synaptic transmission; neuronal action potential; and vitamin D receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

776 residues, UniProt reviewed canonical sequence.

>Q6ZVF9|GPRIN3
     1  MGTVPDPLRS AKTSLIAASG KEDDLGEPQA ASPRHRPALL CKNANGFSGA PAEPDLSPRA
    61  AAEALMQVCE HETTQPDMSS PGVFNEVQKA PATFNSPGNP QLPGSSQPAA SAPSSAAGRD
   121  LIHTPLTMPA NQHTCQSIPG DQPNAITSSM PEDSLMRSQR TSNREQPEKP SCPVGGVLSS
   181  SKDQVSCEFP SPETIQGTVQ TPVTAARVVS HSSSPVGGPE GERQGAICDS EMRSCKPLTR
   241  ESGCSENKQP SVTASGPQGT TSVTPQPTPL TSEPSACPPG PEKVPLPAQR QMSRFKEAST
   301  MTNQAESEIK EVPSRAWQDA EVQAVASVES RSVSTSPSIL TAFLKESRAP EHFEQEQLRV
   361  ICHSSGSHTL ELSDSTLAPQ ESSQCPGIMP QVHIQAAAAE STAFQRENKL ASLPGGVLKT
   421  SSINLVSSNA QHTCKEDGRL AGMTPVREES TAKKLAGTNS SSLKATAIDQ ISISACSQAE
   481  TSYGLGKFET RPSEFAEKTT NGHKTDPDCK LSDSCGSISK ADHSGSLDPT NKGDAREKKP
   541  ASPQVVKEKE STGTDTSDAK TLLLNPKSQE SGGTESAANP TPSPIRKNQE STLEENRQTK
   601  TATSLSLPSD PMGDSSPGSG KKTPSRSVKA SPRRPSRVSE FLKEQKLNVT AAAAQVGLTP
   661  GDKKKQLGAD SKLQLKQSKR VRDVVWDEQG MTWEVYGASL DAESLGIAIQ NHLQRQIREH
   721  EKLIKTQNSQ TRRSISSDTS SNKKLRGRQH SVFQSMLQNF RRPNCCVRPA PSSVLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
lymph node: 9.5 nTPM
appendix: 8.5 nTPM
tonsil: 7.4 nTPM
bone marrow: 7.3 nTPM
lung: 6.7 nTPM

Single-cell type

t-cells: 338 nCPM
nk-cells: 264 nCPM
somatotrophs: 225 nCPM
thyrotrophs: 219 nCPM
microglia: 208 nCPM
macrophages: 207 nCPM

Immune cell

MAIT T-cell: 3.8 nTPM
T-reg: 3.4 nTPM
gdT-cell: 2.8 nTPM
memory CD4 T-cell: 2.7 nTPM
memory CD8 T-cell: 2.2 nTPM
NK-cell: 1.9 nTPM

Brain region

cerebellum: 42 nTPM
basal ganglia: 24 nTPM
hypothalamus: 20 nTPM
midbrain: 19 nTPM
white matter: 17 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -1.01
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRIN3 as an antibody target. Whether an autoantibody or antibody against GPRIN3 could matter depends on whether native GPRIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRIN3 is annotated at the cell surface, where native GPRIN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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