Seroatlas · Human Serome Atlas

GPRASP3

G protein-coupled receptor associated sorting protein 3

Also known as: BHLHB9, GASP3, GASP3_HUMAN, KIAA1701, p60TRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PI77
Gene: GPRASP3
Ensembl: ENSG00000198908
Chromosome: X
Canonical length: 547 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q6PI77|GPRASP3
     1  MAGTKNKTRA QAKTEKKAAI QAKAGAEREA TGVVRPVAKT RAKAKAKTGS KTDAVAEMKA
    61  VSKNKVVAET KEGALSEPKT LGKAMGDFTP KAGNESTSST CKNEAGTDAW FWAGEEATIN
   121  SWFWNGEEAG NSFSTKNDKP EIGAQVCAEE LEPAAGADCK PRSGAEEEEE ENVIGNWFWE
   181  GDDTSFDPNP KPVSRIVKPQ PVYEINEKNR PKDWSEVTIW PNAPAVTPAV LGFRSQAPSE
   241  ASPPSYIVLA SAEENACSLP VATACRPSRN TRSCSQPIPE CRFDSDPCIQ TIDEIRRQIR
   301  IREVNGIKPF ACPCKMECYM DSEEFEKLVS LLKSTTDPLI HKIARIAMGV HNVHPFAQEF
   361  INEVGVVTLI ESLLSFPSPE MRKKTVITLN PPSGDERQRK IELHVKHMCK ETMSFPLNSP
   421  GQQSGLKILG QLTTDFVHHY IVANYFSELF HLLSSGNCKT RNLVLKLLLN MSENPTAARD
   481  MINMKALAAL KLIFNQKEAK ANLVSGVAIF INIKEHIRKG SIVVVDHLSY NTLMAIFREV
   541  KEIIETM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRASP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 9.4 nTPM
cerebellum: 6.8 nTPM
hypothalamus: 6.7 nTPM
retina: 6.5 nTPM
basal ganglia: 5.8 nTPM
hippocampal formation: 4.7 nTPM

Single-cell type

other brain neurons: 34 nCPM
brain excitatory neurons: 33 nCPM
brain inhibitory neurons: 30 nCPM
oligodendrocyte progenitor cells: 30 nCPM
choroid plexus epithelial cells: 29 nCPM
oligodendrocytes: 27 nCPM

Immune cell

NK-cell: 1.7 nTPM
memory CD8 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM
T-reg: 0.5 nTPM
MAIT T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

hypothalamus: 22 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 19 nTPM
pons: 18 nTPM
medulla oblongata: 15 nTPM
white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRASP3 as an antibody target. Whether an autoantibody or antibody against GPRASP3 could matter depends on whether native GPRASP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRASP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPRASP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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